Neurotrophic factors and regeneration in the peripheral nervous system
نویسندگان
چکیده
منابع مشابه
Neurotrophic Factors in Peripheral Nervous System Development: Function & Specificity
Neurotrophic factors control a range of activities in developing neurons, including survival, proliferation, migration and neuronal differentiation. Two classes of neurotrophic factors that are strongly linked to neuronal development of the peripheral nervous system are the neurotrophins and GDNF family ligands. Like other trophic factors they act by triggering signalling through receptor tyros...
متن کاملPeripheral nerve regeneration and neurotrophic factors.
The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells has been the subject of numerous studies. Administration of exogenous neurotrophic factors after nerve injury has been shown to mimic the effect of target organ-derived trophic factors on neuronal cells. After axotomy and during peripheral nerve regeneration, the neurotrophins NGF, NT-3 and BDNF show a...
متن کاملPeripheral Nerve Regeneration: Cell Therapy and Neurotrophic Factors.
Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for nerve repair. Among these, the tubulization technique can be highlighted: this allows regenerative factors to be introduced into the chamber. Cell therapy and tissue engineering have arisen as an alternative for stimulating and ...
متن کاملPlasticity and regeneration in the peripheral nervous system.
While in the central nervous system plasticity (in response to stimulus) and regeneration (in response to injury) are mainly based on adaptive changes in neural circuitries and synaptic reorganization, in the peripheral nervous system they are predominantly based on axonal (re)growth and neuron addition. In this paper, we will briefly overview the main investigation lines on plasticity and rege...
متن کاملAstroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.
Embryonic and neonatal neurons require specific trophic supplements for their survival and the induction of transmitter-synthesizing enzymes in vivo and in vitro. Acidic and basic fibroblast growth factor (aFGF, bFGF) and the closely related astroglial growth factors AGF-1 and AGF-2 were studied for putative neurotrophic functions using dissociated, highly neuron-enriched cultures from chick an...
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ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 1984
ISSN: 0306-4530
DOI: 10.1016/0306-4530(84)90001-5